IL-6
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Description
IL-6 is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. IL-6 is an important mediator of fever and of the acute phase response, is capable of crossing the blood-brain barrier and initiating synthesis of PGE2 in the hypothalamus, thereby changing the body's temperature setpoint. In muscle and fatty tissue, IL-6 stimulates energy mobilization that leads to increased body temperature. IL-6 can be secreted by macrophages in response to pathogen-associated molecular patterns (PAMPs) antigens. IL-6 can be modulated by chemopreventive drugs, small molecules, monoclonal antibodies, and immune checkpoint inhibitors (Unver and McAllister 2018). IL-6 is an important biomarker used in infectious and autoimmune diseases, cancer, neurodegenerative and cardiovascular diseases, and aging (Erol 2007). There is just one commercially available mAb specific for marmoset IL-6 (www.Ucytech.com), which so far has not been employed in published studies.
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Alignment
Protein alignment for human, rhesus macaque and marmoset IL-6:
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Protein alignment for marmoset, owl monkey, and squirrel monkey IL-6:
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References
- Erol, A. (2007). "Interleukin-6 (IL-6) is still the leading biomarker of the metabolic and aging related disorders." Med Hypotheses 69(3): 708.
- Unver, N. and F. McAllister (2018). "IL-6 family cytokines: Key inflammatory mediators as biomarkers and potential therapeutic targets." Cytokine Growth Factor Rev 41: 10-17.
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Status
Several monoclonal antibody pairs have been developed and are being validated.
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