CD69
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Description
CD69 is a membrane鈥恇ound, type II C鈥恖ectin receptor, usually identified as a classical early marker of lymphocyte activation, due to its rapid appearance on the surface of the plasma membrane after stimulation. CD69 is expressed by several subsets of tissue resident immune cells, including resident memory T (TRM) cells and gamma delta (gd) T cells, and is therefore considered a marker of tissue retention. Recent evidence has revealed that CD69 regulates the differentiation of regulatory T cells (Treg) as well as the secretion of IFN鈥恎, IL鈥17, and IL鈥22 (Cibrian and Sanchez-Madrid 2017).
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Alignment
Protein alignment for human, rhesus macaque and marmoset CD69:
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Protein alignment for marmoset, owl monkey, and squirrel monkey CD69:
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References
- Cibrian, D. and F. Sanchez-Madrid (2017). "CD69: from activation marker to metabolic gatekeeper." Eur J Immunol 47(6): 946-953.
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Status
Several monoclonal antibody have been developed and are being validated.
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