Granzyme B
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Description
The predominant pathway used by CD8+ T cells to kill pathogen-infected cells is granule exocytosis, involving the release of Granzyme B (GB). GB is a serine protease which cleaves various caspases inside the target cell, this triggers apoptosis and death of the infected cell. GB release is a hallmark of activated cytotoxic T cells and is thus an important marker to measure in vaccine development and when studying correlates of protection against intracellular infections (Hiebert and Granville 2012).
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Alignment
Protein alignment for marmoset, owl monkey, and squirrel monkey granzyme B:
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References
- Hiebert, P. R. and D. J. Granville (2012). "Granzyme B in injury, inflammation, and repair." Trends Mol Med 18(12): 732-741.
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Status
Mice have been immunized with recombinant marmoset protein.
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